For more than four decades, PIRE scientists have carried out hundreds of research projects funded by the National Institutes of Health and other agencies that have contributed to the development of more effective prevention, treatment, and safety strategies. Across its six major locations, PIRE researchers utilize a wide range of research modalities, including community trials, survey research, geospatial research, cost-benefit analysis, legal and legislative analysis, computer simulation modeling, and meta-analysis. We are equally adept at implementing community-based participatory research projects to randomized controlled trials across multiple communities. PIRE’s Center in Berkeley, CA, has served for more than 40 years as the national Prevention Research Center for the National Institute on Alcohol Abuse and Alcoholism, leading the nation in research on environmental strategies to prevent and reduce consequences of harmful alcohol use. Across all our centers, we have undertaken important domestic and international research studies on a host of public and behavioral health topics, including substance abuse, mental health and wellbeing, HIV and STIs, traffic safety, injury, violence, and health economics.