Government policies, regulations, and laws, as well as formal and informal organizational policies, have powerful impacts on behaviors and overall public health and safety. PIRE researchers and policy analysts identify, develop, and evaluate effective public health and safety policies on national, state, and local levels. PIRE’s research and analysis have encompassed a variety of policy areas, including traffic safety, drugs and alcohol, tobacco, violence, firearms, educational programming, and health care financing. PIRE has also developed simulation models, which enable decision-makers to explore alternative policy scenarios and predict the benefits of different policies or combinations of policies. Examples of computer models for simulation purposes that have been developed by PIRE include SimCom, a simulation model used to examine alternative strategies for reducing alcohol problems in a community or state, and SimSmoke, which tests alternative policy strategies to reduce smoking levels and initiation rates among the national population. PIRE was also instrumental in the development of alcohol (APIS) and recreational use of cannabis models that examine policies associated with these substances https://alcoholpolicy.niaaa.nih.gov/.