Alcohol Interlock and Biomarker Prediction of DUI Risk

Principal Investigator: Paul Marques
Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
(6/13/2003 - 5/31/2009)

Proposal Abstract
This multinational study examined objective alcohol-risk indicators from multiple sources. This study was conducted in Alberta Canada; samples for analysis were shipped to laboratories in the US, Germany, Sweden, and Luxembourg. All 534 DUI offenders in the study conducted in provided informed consent and used an alcohol ignition interlock device, the record of which is a strong predictor of future DUI .The study evaluated blood-borne biomarkers of alcohol-related problems (ALT, AST, %CDT, GGT, MCV) and some direct markers of consumption (blood PEth, EtG in hair and FAEE in hair, and EtG/EtS in urine). These markers together with driver records and validated self-report assessment instruments (TLFB, AUDIT, DIS-AM, TRI, DrInC) were used to develop aggregate predictive profiles for future DUI.